Will the proteins in Restylane cause an allergic reaction?

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Question: I have proved to be allergic to several medications in the past that were animal derived. Will the proteins in Restylane cause an allergic reaction at the injection site?

Answer: There are no proteins in Restylane. Restylane is simply composed of hyaluronic acid, which is sugar molecules linked together thousands of times, and then these chains are cross-linked against themselves. It is a substance that is naturally found in all humans, and you, therefore, should not be able to have an allergic reaction to it. If you are extremely concerned about this unlikely situation, then possibly a small test injection on a forearm or behind the ear would be appropriate just to make sure that you tolerate the filler material before the syringe is actually placed. Assuming that you have no reaction, then I would feel quite comfortable performing Restylane injection on you without concern for any sort of reaction.

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